Journal: Discover oncology
Article Title: Oral cancer driver gene mutations in oral potentially malignant disorders: clinical significance and diagnostic implications.
doi: 10.1007/s12672-025-01923-7
Figure Lengend Snippet: Fig. 5 OLP case with ODGM. a–d Case with ODGM (case 15). a At the initial presentation, we observed non-removable white patches with mottled appearance and surrounding redness, leading to a clinical diagnosis of OLP. b A biopsy confirmed the histopathological diagnosis of OLP. c Eleven months after the initial presentation, a thickened white patch was observed on the posterior buccal mucosa. d A second biopsy led to a histopathological diagnosis of OED. e, f OLP case without ODGMs (Case 24). e Oral cavity image. f H&E staining. g Timeline of clinical course for case 15. ODGM, oral cancer driver gene mutation; OED, oral epithelial dysplasia; OLP, oral lichen planus; NGS, next- generation sequencing
Article Snippet: Thus, we developed a custom target gene sequencing panel (AmpliSeq for Illumina Customs DNA Panel) capable of detecting full-length mutations in TP53, NOTCH1, CDKN2A, FBXW7, as well as mutations in HRAS, PIK3CA, and BRAF.
Techniques: Biomarker Discovery, Staining, Mutagenesis, Next-Generation Sequencing